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Mika O'Shea was good in the cage for Oxy, totaling 14 saves.
Mackenzie Wooten, Brittany Percin and Katie Johnston each scored two goals for Caltech.
The Tigers improve to 3-16 overall and 2-8 in SCIAC play.
Caltech falls to 0-18 and 0-10.
Oxy returns to action against Pomona-Pitzer on April 7 at 11 a.m.Follow Oxy Athletics on Twitter Sign Up for Newsletters Watch on Youtube Follow us on Instagram